Sistema di Puntamento
You can now explicitly target an individual in NWN2 (unlike NWN1 where targets were implicity selected). This is very similar to WoW. You can then perform actions on this target very rapidly. For example, I have a hostile goblin selected, I cast Magic Missle (through one of the several methods we have available for casting spells) and the goblin will be on the receiving end of the Magic Missle without needing to target him again, again very similar to WoW. If I still have that same goblin targeted while I select Cure Light Wounds, my mouse cursor will turn into the Spell Target Cursor and I can then choose an approriate target for that spell since I cannot (and would not) cast CLW on a hostile goblin.
To cast spells, you can use either the hotbar system (some call it a quickbar) OR you can use the new Quick Cast System. The Quick Cast System is a mini menu system that pops up with a key press (currently defined as 'F' on my machine because I use the WASD keys to drive). Once the Quick Cast System pops open, I can quickly select an available spell. After selecting the spell, the Quick Cast System automatically closes to prevent obscuring the screen. Yes, this also works with Bards, Sorcerers, and MetaMagic feats and No, I am not going into more detail right now.
The old radial menu system as you know it going away. It is being replaced by the Context Sensitive Menu that Josh has covered extensively. I personally feel that with the new system, things have gotten MUCH easier to use. This menu system works very similar (some would say identical) to the way the context system works in most modern operating systems and in Fallout.
In addition to all of this, we are including something we call the 'Mode' bar. The Mode bar is where you will AUTOMATICALLY find all the various modes your character can go into (such as sneak and power attack). This small bar is collapsable and also draggable.
Finally, the hotbar system has completely changed. Your hotbar system will allow for a great deal of customization through the XML system. you can create sidebars (ala WoW) and you can add more or less to the screen as you see fit. We intend to allow some degree of flexibilty to the key binding customization as well. Our hotbar system is MOST similar to the one WoW has.
More on the hotbar, it is NOT one set of hotbar buttons for your entire party. EACH character in the party under your control has thier OWN set of hotbar buttons. That's 144 buttons per character. If I had 3 people in my party, each character would have their OWN set of 144 buttons (though this might drop to 10x12 for 120). If that is too many buttons for you, don't use them all. However I think that when you see some of the other cool unannounced functionality for the hotbar that people will find all sorts of cool uses for the extra buttons and bars.
The default hotbar key bindings work almost IDENTICAL to WoW. Pressing 1 thorugh = will activate the corresponding BUTTON for the currently active HOTBAR. To rapidly switch to another hotbar, you currently use shift + a corresponding key (shift+2 will switch to the 2nd hotbar). Alternatively, you can use the little up and down arrow buttons on the hotbar. Again, this is not a new or foreign concept for hotbars. Many other successful games use the same or a very similar sytem.
I will answer as many specific questions as I can (without releasing information that is still top secret) as long as the discourse is polite.